Features Of Aquaporin-4 Antibody

BACKGROUND and PURPOSE. Longitudinally extended transverse myelitis, a spinal manifestation of neuromyelitis optica Spectrum Disorders, is well-documented. However, other forms of nontumorous myelopathy may also present as longitudinally extensive transverse. 

Our goal was to assess the MR imaging characteristics of aquaporin-4 antibody-positive longitudinally extensive transverse myelitis. This condition is strongly linked with neuromyelitis optica. You can also look for anti-aquaporin 4/AQP4 antibody picoband online.

Aquaporin-4 Antibody (NBP1-87679): Novus Biologicals

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MATERIALS & METHODS: We assessed cervicomedullary joint involvement, cord expansion rates, bright spotty lesion count, number of involved segments, enhancement patterns, and axial distribution patterns by using spinal MR imaging. 

This was done on 41 patients suffering from longitudinally extensive transverse myelitis. To identify factors that are associated with aquaporin-4 antibody seropositivity, a univariate logistic regression analysis was done. 

These factors were used to create a scoring system to diagnose aquaporin-4-positive longitudinally extended transverse myelitis. 

The intraclass correlation coefficients (and k) were used to determine interrater reliability in cord expansion ratio measurement and bright spotty lesion detection.

RESULTS: Aquaporin-4 antibody was positive in 15 patients with longitudinally extended transverse myelitis. Aquaporin-4 antibody seropositivity was significantly linked to gender (female), cervicomedullary joint involvement, cord expansion ratio >1.4, and bright spotty lesion. 

The scoring system had a sensitivity of 73.3% and specificity at 96.2%, respectively. The interclass correlation value of the cord expansion ratio was 0.78 and the k value was 0.61 for the bright spotty lesion.

CONCLUSIONS: Our scoring system, based on cervicomedullary junction involvement, higher cord expansion ratio, bright spotty lesions, and female, can facilitate the timely diagnosis of neuromyelitis optica spectrum disorders.